Omega-3 Fish Oil Supplements

Prenatal supplementation helps the body to use key nutrients for fetal brain development more efficiently

Omega-3 fish oil supplements

A recent study shows that taking 500 milligrams of the nutrient choline helps the body more efficiently metabolize an omega 3 fatty acid that is crucial for the fetus’ brain, cognition and vision development.

Choline helps the body use an important nutrient during a baby’s development

The nutrient choline has already been shown to have long-term benefits for children whose mothers eat it throughout pregnancy. However, a recent study has shown that it can also help the body to use an omega 3 fat more effectively

acid
Any substance which, when dissolved in water, gives a pH lower than 7.0, or which donates a hydrogen ion.

“data-gt-translate-attributes =”[{” attribute=””>acid that is crucial for the fetal brain, cognition, and eyesight development.

The research was published in the American Journal of Clinical Nutrition on May 16th, 2022.

The results demonstrate that choline supplementation helps cellular metabolism more effectively manage and release the omega 3 fatty acid, Cornell University. Kevin Klatt, Ph.D. ’18, a researcher and registered dietitian at University of California, Berkeleyis the magazine’s first author.

These forms of interactions between nutrients and nutrients are not new, according to Caudill. In the intestines, for example, vitamin D improves calcium uptake while vitamin C increases iron supply.

Caudill and colleagues at Cornell have also shown that high maternal choline intake reduces infants’ stress responses, improves information processing and has long-term benefits in sustained attention (as shown in a study that followed children up to 7 years), and that choline reduces a factor that contributes to pregnancy poisoning in pregnant women.

In this study, a group of 30 women during pregnancy weeks 12 to 16 was randomly divided into two groups: One received 500 milligrams of choline per day plus 50 milligrams of choline per day marked with deuterium, so that it could be traced through the body. The second group acted as a control and received 25 milligrams per day of just the labeled choline. All participants also received a daily 200 milligram DHA supplement, a prenatal vitamin and mineral supplement, and were able to eat their normal diet. Blood and urine were taken after fasting at the beginning of the experiment for a baseline, and then during the pregnancy weeks 20-24 and weeks 28-30. Maternal blood and umbilical cord blood were also taken at delivery.

By tracing the labeled choline, the researchers identified a chemical reaction in which choline donates small molecules called methyl groups that are added to a molecule called phosphatidylethanolamine. Through a biological pathway, phosphatidylethanolamine is converted to a new choline-containing molecule, phosphatidylcholine, which is enriched in DHA. In this form, DHA is transferred out of the liver and into a mother’s bloodstream, where it is available for use in tissues.

Future work will help determine if choline’s ability to improve DHA bioavailability contributes to some of the benefits that exist when pregnant women supplement choline.

“Our results suggest that choline supplementation may help achieve higher DHA status with lower DHA doses during pregnancy,” Klatt said. “Our data point to choline intake as another important determinant of the amount of DHA in the diet that makes it into tissues during pregnancy.”

Co-authors include researchers from Baylor College of Medicine; the

University of California, Berkeley
Located in Berkeley, California and founded in 1868, the University of California, Berkeley is a public research university that also runs through UC Berkeley, Berkeley, California or Cal. It maintains close relationships with three DOE National Laboratories: Lawrence Berkeley National Laboratory, Los Alamos National Laboratory and Lawrence Livermore National Laboratory.

“data-gt-translate-attributes =”[{” attribute=””>University of California, Berkeley; Chiang Mai University, Chiang Mai, Thailand; OmegaQuant Analytics in Sioux Falls, South Dakota; the University of British Columbia in Vancouver; Cayuga Medical Center in Ithaca; and the University of Texas, Austin.

The study was funded by the Balchem Corporation; the Cornell Institute of Biotechnology’s Center for Advanced Technology through the New York State Division of Science, Technology and Innovation; and the United States Department of Agriculture. The funding sources had no role in the study design, data interpretation or publication of results.

Reference: “Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid status among pregnant participants consuming supplemental DHA: a randomized controlled trial” by Kevin C Klatt, Melissa Q McDougall, Olga V Malysheva, Siraphat Taesuwan, Aura (Alex) P Loinard-González, Julie E H Nevins, Kara Beckman, Ruchika Bhawal, Elizabeth Anderson, Sheng Zhang, Erica Bender, Kristina H Jackson, D Janette King, Roger A Dyer, Srisatish Devapatla, Ramesh Vidavalur, J Thomas Brenna and Marie A Caudill, 16 May 2022, American Journal of Clinical Nutrition.
DOI: 10.1093/ajcn/nqac147


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